NUAA NSW - ⚠️Drug Warning ⚠️ High/variable dose MDMA ⚠️ April 29th 2020⚠️ NSW Health has released a drug warning about high-dose MDMA pressed pills (AKA 'ecstasy' tablets) currently circulating in NSW.
Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”): The Influence of Gender and Genetics (CYP2D6, COMT, 5-HTT) | PLOS ONE
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Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats | BMC Pharmacology and Toxicology | Full Text
![Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons | Molecular Psychiatry Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons | Molecular Psychiatry](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fmp.2013.97/MediaObjects/41380_2014_Article_BFmp201397_Fig1_HTML.jpg)
Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons | Molecular Psychiatry
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Behavioral and Neurochemical Consequences of Long-Term Intravenous Self-Administration of MDMA and Its Enantiomers by Rhesus Monkeys | Neuropsychopharmacology
![Frontiers | Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (“Ecstasy”) in Rats and Preserves Affinity for the Serotonin Transporter (SERT) Frontiers | Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (“Ecstasy”) in Rats and Preserves Affinity for the Serotonin Transporter (SERT)](https://www.frontiersin.org/files/MyHome%20Article%20Library/446660/446660_Thumb_400.jpg)
Frontiers | Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (“Ecstasy”) in Rats and Preserves Affinity for the Serotonin Transporter (SERT)
![Distinct neural mechanisms for the prosocial and rewarding properties of MDMA | Science Translational Medicine Distinct neural mechanisms for the prosocial and rewarding properties of MDMA | Science Translational Medicine](https://www.science.org/cms/10.1126/scitranslmed.aaw6435/asset/4f53bc8f-610b-41e7-8d83-920756d0a180/assets/graphic/aaw6435-f1.jpeg)
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA | Science Translational Medicine
![Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats | BMC Pharmacology and Toxicology | Full Text Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats | BMC Pharmacology and Toxicology | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs40360-019-0326-6/MediaObjects/40360_2019_326_Fig2_HTML.png)
Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats | BMC Pharmacology and Toxicology | Full Text
![Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons - The Lancet Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons - The Lancet](https://www.thelancet.com/cms/attachment/2119419190/2093594003/gr1.gif)
Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons - The Lancet
![Pill content, dose and resulting plasma concentrations of 3,4‐methylendioxymethamphetamine (MDMA) in recreational 'ecstasy' users - Morefield - 2011 - Addiction - Wiley Online Library Pill content, dose and resulting plasma concentrations of 3,4‐methylendioxymethamphetamine (MDMA) in recreational 'ecstasy' users - Morefield - 2011 - Addiction - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/ca9c925c-676d-46c5-a5df-5c34cce3cc0a/add_3399_f4.gif)
Pill content, dose and resulting plasma concentrations of 3,4‐methylendioxymethamphetamine (MDMA) in recreational 'ecstasy' users - Morefield - 2011 - Addiction - Wiley Online Library
![Pharmacokinetic Profile of Single and Repeated Oral Doses of MDMA in Squirrel Monkeys: Relationship to Lasting Effects on Brain Serotonin Neurons | Neuropsychopharmacology Pharmacokinetic Profile of Single and Repeated Oral Doses of MDMA in Squirrel Monkeys: Relationship to Lasting Effects on Brain Serotonin Neurons | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsj.npp.1300808/MediaObjects/41386_2006_Article_BF1300808_Fig1_HTML.gif)
Pharmacokinetic Profile of Single and Repeated Oral Doses of MDMA in Squirrel Monkeys: Relationship to Lasting Effects on Brain Serotonin Neurons | Neuropsychopharmacology
![The Loop on X: "Multiple #TeddyBear pills in circulation this summer in different colours & strengths. The Loop has tested >20 Teddy Bears; all contained MDMA, averaging ~180mg (common adult MDMA dose The Loop on X: "Multiple #TeddyBear pills in circulation this summer in different colours & strengths. The Loop has tested >20 Teddy Bears; all contained MDMA, averaging ~180mg (common adult MDMA dose](https://pbs.twimg.com/media/FYX4RHdWQAIFtUJ.jpg:large)
The Loop on X: "Multiple #TeddyBear pills in circulation this summer in different colours & strengths. The Loop has tested >20 Teddy Bears; all contained MDMA, averaging ~180mg (common adult MDMA dose
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